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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K5
All Species:
35.15
Human Site:
S248
Identified Species:
55.24
UniProt:
Q13163
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13163
NP_002748.1
448
50112
S248
T
E
F
M
D
G
G
S
L
D
V
Y
R
K
M
Chimpanzee
Pan troglodytes
XP_001174798
467
51808
S248
T
E
F
M
D
G
G
S
L
D
V
Y
R
K
M
Rhesus Macaque
Macaca mulatta
XP_001111645
449
50213
S249
T
E
F
M
D
G
G
S
L
D
V
Y
R
K
M
Dog
Lupus familis
XP_852868
288
32448
Y113
A
V
V
K
G
L
T
Y
L
W
S
L
K
I
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVS7
448
50086
S248
T
E
F
M
D
G
G
S
L
D
V
Y
R
K
I
Rat
Rattus norvegicus
Q62862
448
50179
S248
T
E
F
M
D
G
G
S
L
D
V
Y
R
K
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516129
399
44778
S199
T
E
F
M
D
G
G
S
L
D
V
Y
R
K
I
Chicken
Gallus gallus
NP_001073184
351
39168
R176
G
G
S
L
D
V
Y
R
K
I
P
E
H
V
L
Frog
Xenopus laevis
NP_001084729
448
49926
S248
T
E
F
M
D
G
G
S
L
D
V
Y
R
K
I
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
T186
E
D
I
L
G
K
I
T
V
S
I
V
K
A
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24324
396
43851
L216
D
V
K
P
S
N
I
L
V
N
S
S
G
E
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10664
387
42776
S205
P
S
N
M
L
V
N
S
N
G
E
I
K
L
C
Sea Urchin
Strong. purpuratus
XP_786275
385
43129
Q198
K
E
I
L
S
E
L
Q
I
L
Y
K
C
D
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94A06
354
39192
Y179
R
V
L
R
G
L
C
Y
I
H
H
E
R
R
I
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
S442
M
E
Y
M
D
G
G
S
L
D
K
I
Y
D
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.3
99.5
63.3
N.A.
97.7
98.2
N.A.
82.3
74.1
84.8
30.5
N.A.
35
N.A.
37
49.3
Protein Similarity:
100
93.3
99.5
64.2
N.A.
99.1
99.1
N.A.
86.1
76.1
89.9
47.3
N.A.
54.2
N.A.
53.7
63.1
P-Site Identity:
100
100
100
6.6
N.A.
93.3
93.3
N.A.
93.3
6.6
93.3
0
N.A.
0
N.A.
13.3
6.6
P-Site Similarity:
100
100
100
20
N.A.
100
100
N.A.
100
20
100
46.6
N.A.
26.6
N.A.
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.8
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
47.5
42.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
53.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% A
% Cys:
0
0
0
0
0
0
7
0
0
0
0
0
7
0
7
% C
% Asp:
7
7
0
0
60
0
0
0
0
54
0
0
0
14
0
% D
% Glu:
7
60
0
0
0
7
0
0
0
0
7
14
0
7
7
% E
% Phe:
0
0
47
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
7
0
0
20
54
54
0
0
7
0
0
7
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
7
7
0
7
0
0
% H
% Ile:
0
0
14
0
0
0
14
0
14
7
7
14
0
7
40
% I
% Lys:
7
0
7
7
0
7
0
0
7
0
7
7
20
47
0
% K
% Leu:
0
0
7
20
7
14
7
7
60
7
0
7
0
7
20
% L
% Met:
7
0
0
60
0
0
0
0
0
0
0
0
0
0
20
% M
% Asn:
0
0
7
0
0
7
7
0
7
7
0
0
0
0
0
% N
% Pro:
7
0
0
7
0
0
0
0
0
0
7
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% Q
% Arg:
7
0
0
7
0
0
0
7
0
0
0
0
54
7
0
% R
% Ser:
0
7
7
0
14
0
0
60
0
7
14
7
0
0
7
% S
% Thr:
47
0
0
0
0
0
7
7
0
0
0
0
0
0
0
% T
% Val:
0
20
7
0
0
14
0
0
14
0
47
7
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
7
14
0
0
7
47
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _